Divergolide congeners illuminate alternative reaction channels for ansamycin diversification.
نویسندگان
چکیده
Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 6 شماره
صفحات -
تاریخ انتشار 2015